Overview of Triple and Quartic Gauge Coupling Measurements at the LHC

Scrutiny of the structure of electroweak gauge boson self-interactions through triple and quartic gauge boson couplings (TGCs and QGCs) constitutes an important part of the physics program of the Large Hadron Collider (LHC). Triboson production and vector boson scattering (VBS) are directly sensitive to QGCs while vector boson fusion (VBF) offers a new window in the study of TGCs, which is complementary to conventional measurements using diboson production. In this contribution, an overview of recent TGC and QCG measurements using triboson production, VBS and VBF by the ATLAS and CMS experiments at the LHC is presented.Comment: proceedings of the LHCP2014 conferenc

Active and reactive power in stochastic resonance for energy harvesting

A power allocation to active and reactive power in stochastic resonance is discussed for energy harvesting from mechanical noise. It is confirmed that active power can be increased at stochastic resonance, in the same way of the relationship between energy and phase at an appropriate setting in resonance.Comment: 3 pages, 4 figure

Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex?

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.Peer reviewedPublisher PD

PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1

Acknowledgments We thank Richard Kolodner, Grant Brown, and Daniel Durocher for strains and plasmids. We thank Anne Donaldson, Alexander Lorenz, and Shin-ichiro Hiraga from University of Aberdeen for careful reading of the manuscript. Research in T.K.’s lab is supported by Medical Research Council Career Development Fellowship L019698/1. V.K.G. was supported by Biotechnology and Biological Sciences Research Council grant K006304/1. T.S.T. was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (nos. 23131507 and 25131712).Peer reviewedPublisher PD

TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription

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Roles of CCN2 as a mechano-sensing regulator of chondrocyte differentiation

Cellular communication network factor 2 (CCN2) is a cysteine-rich secreted matricellular protein that regulates various cellular functions including cell differentiation. CCN2 is highly expressed under several types of mechanical stress, such as stretch, compression, and shear stress, in mesenchymal cells including chondrocytes, osteoblasts, and fibroblasts. In particular, CCN2 not only promotes cell proliferation and differentiation of various cells but also regulates the stability of mRNA of TRPV4, a mechanosensitive ion channel in chondrocytes. Of note, CCN2 behaves like a biomarker to sense suitable mechanical stress, because CCN2 expression is down-regulated when chondrocytes are subjected to excessive mechanical stress. These findings suggest that CCN2 is a mechano-sensing regulator. CCN2 expression is regulated by the activation of various mechano-sensing signaling pathways, e.g., mechanosensitive ion channels, integrin-focal adhesion-actin dynamics, Rho GTPase family members, Hippo-YAP signaling, and G protein-coupled receptors. This review summarizes the characterization of mechanoreceptors involved in CCN2 gene regulation and discusses the role of CCN2 as a mechano-sensing regulator of mesenchymal cell differentiation, with particular focus on chondrocytes

Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation

Open Access funded by Medical Research Council Acknowledgments We thank Dr Anja Bielinsky for plasmids and Dr. M.K. Raghuraman for a cdc9-1 strain. Alexander Lorenz (University of Aberdeen) provided valuable comments on the manuscript. This work was supported by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/K006304/1 to A.D., Medical Research Council Career Development Fellowship MR/L019698/1 to T.K., and MEXT Grant-in-Aid for Scientific Research on Innovative Areas to K.S.Peer reviewedPublisher PD

SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes

Acknowledgements We thank Karl Kuchler, Carol Munro, Donna MacCallum, Delma Childers and Ian Stansfield for plasmids and strains; Ben Rutter, Madeleine Murray and Tom Jayasekara for help with material constructions and homology search; Vamsi Gali, Anne Donaldson, Yuki Katou and Katsuhiko Shirahige for preliminary ChIP-seq data; Shin-ichiro Hiraga for MaxQuant analysis; Stefan Hoppler for access for equipment; Sophie Shaw and Antonio Ribeiro for bioinformatic analysis of the RNA-seq data and also data uploading to ArrayExpress and Anne Donaldson and Alexander Lorenz for careful reading of the manuscript. We are grateful to the core facilities at University of Aberdeen: the CGEBM facility for help with ChIP-seq and RNA-seq (Ewan Campbell and Zeynab Heidari), the Proteomics facility for mass spectrometry (David Stead) and the qPCR facility. Work was supported by Medical Research Council (MRC) Career Development Fellowship L019698/1 to T.K., and Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z to T.K. and D.M.Peer reviewedPublisher PD

Path planning for planetary rover using extended elevation map

This paper describes a path planning method for planetary rovers to search for paths on planetary surfaces. The planetary rover is required to travel safely over a long distance for many days over unfamiliar terrain. Hence it is very important how planetary rovers process sensory information in order to understand the planetary environment and to make decisions based on that information. As a new data structure for informational mapping, an extended elevation map (EEM) has been introduced, which includes the effect of the size of the rover. The proposed path planning can be conducted in such a way as if the rover were a point while the size of the rover is automatically taken into account. The validity of the proposed methods is verified by computer simulations